Vitamin E

Roaccutane- Vitamin A (Isotretinoin) in a Capsule

This product is available for the treatment of severe acne.

However, it must be noted that the product is usually only prescribed by a skin specialist because it has many adverse effects.

It is NOT to be taken by pregnant ladies because it will cause teratogenicity (ie babies born will have physical defects).

Not to be used with Tetracycline antibiotics because it may cause increased in intracranial pressure and may be lead to fatality. 

Other Contraindications & Precautions:

1. Use effective contraception for one month before, during and at least one month after treatment.
2. Breast-feeding must stop before treatment can start.
3. An allergy to Roaccutane, Vitamin A, or other retinoids.
4. Kidney or liver disease.
5. Very high levels of fat (triglycerides, cholesterol) in the blood. 
6. Excessive amount of Vitamin A in your diet (hypervitaminosis A). 

Below is an article from wikipedia (abridged) regarding the above product. Please read 
carefully. http://en.wikipedia.org/wiki/Isotretinoin

Clinical use

Except in the most severe cases, isotretinoin is used only after other acne treatments fail to produce results. Treatment of acne usually begins with topical medications (e.g. benzoyl peroxide, adapalene, etc.), followed by oral antibiotics (or a combination) and finally isotretinoin therapy. This is because other treatments, while less effective than isotretinoin, are thought to be associated with fewer adverse effects and lower cost.

Indications

Isotretinoin is indicated for the treatment of severe cystic acne vulgaris.Many dermatologists also support its use for treatment of lesser degrees of acne that prove resistant to other treatments, or that produce physical or psychological scarring.

It is also effective for hidradenitis suppurativa and some cases of severe acne rosacea.It can also be used to help treat harlequin ichthyosis, and is used in xeroderma pigmentosum cases to relieve keratoses. Isotretinoin has been used to treat the extremely rare condition fibrodysplasia ossificans progressiva. It is also used for treatment of neuroblastoma, a form of brain cancer.

Prescribing restrictions
 
In the United Kingdom, this drug may only be prescribed by, or under the supervision of, a consultant dermatologist. A physician may not prescribe more than a 30-day supply. A new prescription may not be written for at least 30 days. 

Dosage
 
The dose of isotretinoin a patient receives is dependent on their weight and the severity of the condition. High dose treatments are administered between 0.5 mg/kg/day to 2 mg/kg/day (usually at 0.5 to 1 mg/kg/day, divided into two doses), for a total treatment of 4–6 months. In some rare cases where the patient's acne is severe or unresponsive the initial course may last up to 9 months. A second course may be used at least 8 weeks following the cessation of the initial course if severe acne recurs. Efficacy appears to be related to the cumulative dose of isotretinoin taken, with a total cumulative dose of 120–150 mg/kg used as a guideline. High dose treatments should only be used as a last resort due to adverse side effects.

Nearly all patients achieve initial clearing of acne during high-dose isotretinoin therapy. Furthermore, about 40% observe complete and long-term remission of the disease following one course of isotretinoin, while another 40% eventually develop less severe recurrent acne, which is treatable with less invasive medications. The remaining 20% relapse significantly enough to warrant an additional course of isotretinoin.

Lower dosage treatments, such as 10–20 mg/day (approximately half the high dosage treatments above), are also highly effective, with greatly diminished side effects.However, such lower dosage courses may be associated with higher relapse rates requiring additional courses of isotretinoin.
 
Adverse effects 

Increasingly higher dosages will result in higher toxicity, resembling vitamin A toxicity.

Adverse drug reactions associated with isotretinoin therapy include:

    * Common: Extreme severe acne flare, dryness of skin, lips and mucous membranes, infection of the cuticles, cheilitis, itch, rosacea, skin fragility, skin peeling, rash, flushing, nose bleeds, dry eyes, diffuse alopecia areata, eye irritation, conjunctivitis, reduced tolerance to contact lenses, hyperlipidaemia, raised liver enzymes, permanent thin skin, headaches, temporary/permanent hair thinning (this could start or continue after treatment), myalgiaarthralgia, back pain. and/or

    * Infrequent: mild acne flare, raised blood glucose level, decreased libido/erectile dysfunction, increased erythrocyte sedimentation rate, fatigue.

    * Rare: impaired night vision; cataracts; optic neuritis; menstrual disturbances; inflammatory bowel disease; pancreatitis; hepatitis; corneal opacities; papilloedema; idiopathic intracranial hypertension; skeletal hyperostosis; extraosseous calcification; psychosis; depression

There are reports of spontaneous, premature epiphyseal closure in acne patients receiving recommended doses of Accutane. The effect of multiple courses of Accutane on epiphyseal closure is unknown.

The following adverse effects have been reported to persist, even after discontinuing therapy: alopecia (hair loss), arthralgias, decreased night vision, inflammatory bowel disease, degenerative disc disease, keloids, bone disease. High dosages of isotretinoin have been reported to cause rosacea (a disease of severe facial skin redness and irritation).

During of a prospective study in Mexico that evaluated the efficacy and safety of isotretinoin in acne, six male patients reported clinical symptoms of depression along with difficulties in maintaining adequate penile erection, suggesting a potential link between isotretinoin and risk of erectile dysfunction.

Patients receiving isotretinoin therapy are not permitted to donate blood during and for at least one month after discontinuation of isotretinoin therapy due to its teratogenicity.Its most common side effects are mucocutaneous and ocular in nature (ie, cheilitis, ocular sicca, and decreased dark adaptation). It can also cause xerosis. Patients should be made aware of these side effects before taking isotretinoin and also that utilization of moisturizers and eye drops can help to mitigate such side effects. Sometimes, however, the dose of isotretinoin needs to be decreased to reduce the induction of side effects.

Teratogenicity (Birth Defects)

Isotretinoin is a teratogen and is highly likely to cause birth defects if taken during pregnancy. A few of the more common birth defects that this drug can cause are hearing and visual impairment, missing or malformed earlobes, facial dysmorphism, and mental retardation. Isotretinoin is contraindicated in pregnancy.

The manufacturer recommends that pregnancy be excluded in female patients two weeks prior to commencement of isotretinoin, and that they should use two simultaneous forms of effective contraception at least one month prior to commencement, during, and for at least one month following isotretinoin therapy.

Depression

Several studies have shown a link between isotretinoin and clinical depression.

Since the 1980s, scientific research has suggested a relationship between isotretinoin administration and the onset of psychological symptoms including depression, suicidal ideation, and psychosis.This finding has prompted members of the scientific community to call for more studies regarding isotretinion's links to depression and suicidal behavior.

Crohn's disease and ulcerative colitis

Several scientific studies have posited that isotretinoin is a possible cause of Crohn's disease and ulcerative colitis in some individuals.

Placenta Bovis

Norefal Injections -(T)hymus, (R)ejuvenation & (P)lacenta Types

Pascorbine Vitamin C

750mg x 5mls

Origin: Germany

100 ampoules per box

This is the latest vitamin C injections we have been able to obtain.

Kojic Acid

This is a relatively new product in the market allegedly containing Kojic Acid. Kojic acid for the purpose of cosmetics as many are aware is actually banned in a few countries including Switzerland, Korea and Japan for its possible mutagenicity effects possibly linked to cancer and other health hazards.


What is available in this preparation is none other than glutathione and vitamin C. So this is yet another repacked products made to look as if it is a new novel product.


The bar code below shows that it is not a real bar code. The number portrayed as the bar code shows it is the wrong sets of numbers for a product said to be made in Japan. This number is only used as voucher codes. It is not a real bar code. A real product made in Japan would bear a different set of numbers. You may refer to our previous article on bar codes. However the packaging we must say is rather impressive, together with the logo of Kyowa Hakko, the purported company that makes it.


This product does not contain Kojic Acid. It is just a name. And it is not made in Japan. The error in the bar code reveals it all:

Product:   Kojic Acid                                           
Bar Code:  9987164432453332     
Origin: Voucher Codes
Significance: This bar code is a false bar code                                                                                                          

Insert on the inside of the box

Supposed Certificate of Authenticity

Below is a newspaper clip from a Chinese daily that reported the fake nature of Kojic Acid.

The Beauty of Bar Codes - Possible Meddling of Products

All original products used for injections and for oral consumption and for topical use, should portray their bar codes clearly. If they are not present, they are not original. No two different products will bear identical numbers.

In this piece, we will summarize the popular brands. They have not all been exhausted because we only include the information on products we can get hold of ourselves. If you may care to submit photos of bar codes on other products, we welcome your contributions and will add them to the list. We are sure the packagers will scramble to have the boxes changed to incorporate new bar code numbers, but we have these already recorded here. Therefore, any future changes will render them useless because their ploy has been exposed and what is revealed here can be kept for posterity.


Codes for verification can be found below:
EAN Codes
Italian Pharmacodes
German Pharmaceuticals


Readers may verify themselves that what is written below is accurate by doing the necessary checks themselves. Readers may also find this information disturbing :

Product	Claimed Origin	Bar Code	Country of Origin	Original or Fake
Laroscorbine Platinium Vit C+ Collagen	France	3421357	France	Identical product as Laroscorbine, therefore this number is a Fake Number
Sentien Cell	UK	5130482 991882773	Does Not Exist Voucher codes	Fake Number
Vitacicol Forte P3000	USA	9761187610318	Does Not Exist	Fake Number
Cell Roma	Italy	No Number	Does Not Exist	No Number
Oxydermal	Germany	No Number	Does Not Exist	No Number
Prolene	Germany	No Number	Does Not Exist	No Number
Kojic Acid	Japan	9987164432453332	Voucher Codes	Fake Number
Tationil Bayer	Italy	No Number	Does Not Exist	Fake Number
Vitacicol (Green Box)	USA	8993156006120	Indonesia	Fake Number
Biome		5997001311783	Hungary	Fake Number
NC24	Japan	2987174436423	Internal use	Fake Number
Lucchini	Switzerland	No Number	Does Not Exist	No Number
MF3 HP 230mg	Switzerland	8360926794301	Italy	Fake Number
MF3 Advance Formula	Switzerland	5232918799527	Does Not Exist	Fake Number (number does not exist but this product is registered in Malaysia)

Product	Claimed Origin	Bar Code	Country of Origin	Original or Fake
Tathion 500	South Korea	8806425034543	South Korea	Original
Vit C Bayer (Laroscorbine)	France	3421357	France	Original
Gerovital	Romania	594470705002141	Romania	Original
Lipostabil	Germany	PZN 3352900	German Pharmaceuticals	Original
Wiedemann Homookomplex	Germany	PZN 0507265	German Pharmaceuticals	Original
Wiedemann Vit B12	Germany	PZN 2260834	German Pharmaceuticals	Original
Melsmon (White box)	Japan	4987546000014	Japan	Original
Tationil Teofarma	Italy	A 026185049	Italian Pharma	Original
Mita C	Japan	4987154434423	Japan	Original